Protein name:
Proline-rich protein 1(PRL1);
Alternative:
Basic proline-rich lacrimal protein;
Organism:
Human (Homo sapiens).
General Annotation
Function:
Opiorphin is an endogenous inhibitor of neprilysin and aminopeptidase N. Inhibits the breakdown of substance P, Mca-BK2 and Met-enkephalin by neprilysin in vitro with IC(50) values of 29 uM, 33 uM and 33 uM respectively. Inhibits the breakdown of Ala-pNA by aminopeptidase N in vitro with an IC(50) of 65 uM. Has a potent analgesic effect when administered to rats by intravenous injection.
Subcellular Location:
Secreted
Protein Attributes:
50:
MKLTFFLGLL | ALISCFTPSE | SQRFSRRPYL | PGQLPPPPLY | RPRWVPPSPP |
100:
PPYDSRLNSP | LSLPFVPGRV | PPSSFSRFSQ | AVILSQLFPL | ESIRQPRLFP |
150:
GYPNLHFPLR | PYYVGPIRIL | KPPFPPIPFF | LAIYLPISNP | EPQINITTAD |
200:
TTITTNPPTT | ATATTSTSTK | PTMTISSSTV | PISSTPEPAT | SISAATPAAS |
248:
TENTTQILAN | RPHTVLLNAT | VQVTTSNQTI | LSSPAFKSFW | QKLFAIFG

Vaild Sequence:
Related Databases
Uniprot: