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Index > Protein center > PROL1(Gene name) > Human
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  • PROL1 (Gene name),
  • Proline-rich protein 1 (Protein name ),  PROL1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    PROL1(BPLP);
    Protein name:
    Proline-rich protein 1(PRL1);
    Alternative:
    Basic proline-rich lacrimal protein;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Opiorphin is an endogenous inhibitor of neprilysin and aminopeptidase N. Inhibits the breakdown of substance P, Mca-BK2 and Met-enkephalin by neprilysin in vitro with IC(50) values of 29 uM, 33 uM and 33 uM respectively. Inhibits the breakdown of Ala-pNA by aminopeptidase N in vitro with an IC(50) of 65 uM. Has a potent analgesic effect when administered to rats by intravenous injection.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    248
    Sequence:
    50:
    MKLTFFLGLL | ALISCFTPSE | SQRFSRRPYL | PGQLPPPPLY | RPRWVPPSPP | 
    100:
    PPYDSRLNSP | LSLPFVPGRV | PPSSFSRFSQ | AVILSQLFPL | ESIRQPRLFP | 
    150:
    GYPNLHFPLR | PYYVGPIRIL | KPPFPPIPFF | LAIYLPISNP | EPQINITTAD | 
    200:
    TTITTNPPTT | ATATTSTSTK | PTMTISSSTV | PISSTPEPAT | SISAATPAAS | 
    248:
    TENTTQILAN | RPHTVLLNAT | VQVTTSNQTI | LSSPAFKSFW | QKLFAIFG
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    KEGG:
    MIM:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human PRL1
    Cat.:
    E10592h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PRL1
    Cat.:
    U10592h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human PRL1
    Cat.:
    P10592Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human PRL1
    Protein for Human PRL1

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    Linearity
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    References
    1. 1.
      "cDNA cloning of an abundant human lacrimal gland mRNA encoding a novel tear protein."
      Dickinson D.P. , Thiesse M.
      Curr. Eye Res.15:377-386(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Lacrimal gland.
    2. 2.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "Human opiorphin, a natural antinociceptive modulator of opioid-dependent pathways."
      Wisner A. , Dufour E. , Messaoudi M. , Nejdi A. , Marcel A. , Ungeheuer M.-N. , Rougeot C.
      Proc. Natl. Acad. Sci. U.S.A.103:17979-17984(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 22-26;FUNCTION;SUBCELLULAR LOCATION;PYROGLUTAMATE FORMATION AT GLN-22;MASS SPECTROMETRY
      tissue: Saliva.
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